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Abstract #2671

Uncovering the biological mechanism of depression based on edge-centric functional connectivity: a correlation study

Fanghui Dong1, Tongpeng Chu1, Ning Mao1, and Haizhu Xie1
1Yantai Yuhuangding Hospital, Yantai, China

Synopsis

Keywords: Brain Connectivity, fMRI (resting state), Major depressive disorder, edge-centric functional connectivity, gene expressionThis study aims to use the combination of the edge-centric functional network (eFC) model with transcribed gene datasets to explore the molecular basis of depression. In our study, we for the first time reported the correlation between eFC and transcriptional profiles in MDD patients. These findings revealed eFC phenotypes in MDD and bridged the gap between transcriptome and neuroimaging. It advanced our understanding of the neurobiological mechanism underlying depression and provided potential biomarkers for the evaluation of MDD treatment.

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Keywords