Abstract #2672

Characterization of cortical reorganization in persons with chronic spinal cord injury using mesoscale graph measures

Farzad V Farahani¹, Cristina Sadowsky^2,3, James J Pekar^4,5, Martin Lindquist¹, and Ann S Choe^4,5

¹Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, ²International Center for Spinal Cord Injury, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁵Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Brain Connectivity, Spinal Cord, graph theory, spinal cord injury, plasticity, reorganizationCortical plasticity contributes to neurological recovery in persons with spinal cord injury (SCI) and can be studied using resting-state fMRI. Global graph measures offer insufficient detail to investigate local changes. Here, we investigated whether mesoscale graph measures provide additional insight. Changes in sensorimotor, visual, and ventral attention networks were revealed. Notably, decreased communication between lower body SMN with the rest of the functional networks across the brain and increased communication within the upper body SMN were observed. This suggests a potential for the mesoscale graph measures' utility in understanding the complex brain functional reorganizations in persons with chronic SCI.

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