Abstract #2676

Exploring effect of rTMS at SMA in Parkinson’s Disease- An fMRI-MVPA study.

Priyanka Bhat¹, S Senthil Kumaran², Vinay Goyal³, Achal K Srivastava⁴, S N Dwivedi⁵, and Madhuri Behari⁶

¹Dept. of Neurology, AIIMS, Delhi, India, ²Dept of Nuc. Mag. Res, AIIMS, Delhi, India, ³Medanta, The Medicity, Delhi, India, ⁴Dept of Neurology, AIIMS, Delhi, India, ⁵Dept. of Biostatistics, AIIMS, Delhi, India, ⁶Dept. of Neurology, Fortis Hospitals, Vasant Kunj, Delhi, India

Synopsis

Keywords: Brain Connectivity, fMRI (task based), Parkinson's Disease, Supplementary Motor Area, Transcranial Magnetic StimulationTranscranial Magnetic stimulation alters cortical connectivity in Parkinson’s disease (PD) imparting clinical benefits. The mechanisms by which this occurs remain unexplored. In this study, Multivariate pattern analyses of task-based connectivity was carried out to understand the effects of rTMS in PD. Visuospatial task based functional MRI was acquired before and after stimulation sessions. Correlation matrices revealed an increased connectivity between left supplementary motor area (SMA) and left primary motor area (M1), suggesting an improvement in the motor network.

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