Abstract #2680

Measuring structural connectivity in migraine: the impact of correcting for region volumes

Ana Matoso¹, Ana R Fouto¹, A. Ruiz-Tagle¹, I. Esteves¹, Gina Caetano¹, Nuno A. Silva², Pedro Vilela³, Raquel Gil-Gouveia^4,5, Patrícia Figueiredo¹, and Rita G Nunes¹

¹Institute for Systems and Robotics- Lisboa and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal, ²Learning Health, Hospital da Luz, Lisbon, Portugal, ³Imaging Department, Hospital da Luz, Lisbon, Portugal, ⁴Neurology Department, Hospital da Luz, Lisbon, Portugal, ⁵Center for Interdisciplinary Research in Health, Universidade Católica Portuguesa, Lisbon, Portugal

Synopsis

Keywords: Brain Connectivity, Data Analysis, MigraineWhen studying structural brain connectivity, there are many normalization strategies that can be employed, however, there is still no consensus on which one is best to use. Hence, in this study, we investigated the impact of normalizing by the region volumes in the context of migraine as this is sometimes done to avoid bias towards higher connectivity in bigger regions. Several metrics showed significant differences between normalization strategies and, more critically, nodal metrics displayed different behaviours when compared between controls and migraineurs.

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