Abstract #2684

Identify the paraventricular thalamic nucleus in humans using a structural connectivity approach

Koji Kamagata¹, Wataru Uchida¹, Christina Andica^1,2, Yasuhito Nagai³, Masaki Nishioka³, Mana Owaki^1,4, Yuya Saito¹, Kaito Takabayashi¹, Akifumi Hagiwara¹, Akihiko Wada¹, Toshiaki Akashi¹, Shigeki Aoki¹, and Tadafumi Kato³

¹Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, ²Faculty of Health Science, Juntendo University, Chiba, Japan, ³Department of Psychiatry, Juntendo University, Tokyo, Japan, ⁴Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan

Synopsis

Keywords: Brain Connectivity, Brain Connectivity

We attempted to identify the paraventricular thalamic nucleus (PVT), which is known to regulate emotion, motivation, stress, and drug- and alcohol-related behaviors in humans. We used data-driven connectivity profiles obtained using probabilistic tractography and a k-means clustering method with diffusion-weighted imaging data. We consistently identified an anatomical connectivity-based parcellation of the PVT in two independent cohorts that included 601 healthy subjects. Furthermore, we discerned the specific structural pattern of the PVT, which agreed with findings from animal studies. Finally, we noted significant correlations between PVT structural and functional connectivity with the limbic structures and drug-, nicotine-, or alcohol-related scores.

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