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Abstract #2685

Application of Diffusion MRI to Characterize Connectome Changes Associated with EED Ablation

Majd Alkhalily1, Laura Currey2, Michael Piper2, and Nyoman D Kurniawan1
1Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, 2The School of Biomedical Sciences, The University of Queensland, Brisbane, Australia

Synopsis

Keywords: Brain Connectivity, Genetic Diseases, Tractography, Connectome, EED, Neurodevelopment, MRI, HARDI

Mutation in embryonic ectoderm development (EED) gene in mice have been shown to exhibit microcephaly at birth, however, the adult phenotype is unknown. This study investigates brain connectivity changes arising from EED ablation in adult mice using high angular resolution diffusion imaging. Three groups of adult mice (homozygotes, heterozygotes, controls) were scanned using 16.4 T to acquire diffusion data. Data was then used to compute iFOD2 maps, probabilistic whole brain tractograms, and the connectomes. Connectomic were compared both connectivity- and network-wise. Homozygotes had abnormal connectivity and network metrics suggesting brain under-development, highlighting the importance of EED’s role in brain development.

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