Abstract #2705

The dependence of the macrovascular transverse R₂’ relaxation and resultant BOLD fMRI signal on vascular position: A simulation study

Xiaole Zhong^1,2 and J. Jean Chen^1,2,3

¹Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Rotman Research Institute, Baycrest Hospital, Toronto, ON, Canada, ³Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Signal Modeling, SimulationsThe R₂’ effect is the foundation of BOLD fMRI contrast. R₂’ is disproportionately sensitive to the presence of macrovasculature, which disrupts the homogeneity of the main magnetic field (B₀), resulting in BOLD signal intensities that may heavily depend on macrovascular orientation and volume but also on vascular position. We simulate the BOLD signal strength in a voxel containing macrovasculature at various vascular positions within the voxel. This simulation highlights an additional source of variability in the macrovascular contributions to R₂’-weighted MRI.

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The dependence of the macrovascular transverse R2’ relaxation and resultant BOLD fMRI signal on vascular position: A simulation study

Synopsis

The dependence of the macrovascular transverse R₂’ relaxation and resultant BOLD fMRI signal on vascular position: A simulation study