Abstract #2747

Towards Look-Locker encoding as an arterial spin labeling mechanism: T1/B1+/perfusion mapping with MR Multitasking

Fardad M Serry¹, Hsu-Lei Lee¹, Shihan Qiu^1,2, Yibin Xie¹, Fei Han^1,3, Hui Han¹, and Anthony G Christodoulou^1,2

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Siemens Medical Solutions, Los Angeles, CA, United States

Synopsis

Keywords: Arterial spin labelling, Arterial spin labelling, multitasking, Look-Locker, B1+, spin history, T1, blood, brain, IR-FLASH, inversion efficiency, white matter, gray matterWe hypothesized that the Look-Locker (LL) effect can label arterial spins without the need for subtraction between different inversion schemes. We developed a multiple-flip-angle, non-selective-inversion MR multitasking brain scan to produce co-registered T1, B1+, and perfusion-weighted maps. Flow-sensitive LL fitting homogenized B1+ maps and produced flow maps combining features of time-of-flight angiography images and PCASL perfusion-weighted images. GM/WM flow ratios were similar to PCASL and the literature range.

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