Abstract #2754

Total Generalized Variation (TGV) Constrained Reconstruction Improves Test-retest Reliability of High Resolution 3D pCASL in Children

Qinyang Shou¹, Xingfeng Shao¹, Kimberly Felix², Rudolf Stollberger³, Megan M Herting², and Danny JJ Wang¹

¹Laboratory of Functional MRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, ²Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ³Institute of Biomedical Imaging, Graz University of Technology, Graz, Austria

Synopsis

Keywords: Arterial spin labelling, BrainWe developed an accelerated multi-delay 3D pCASL scheme with high-resolution (iso-2mm), CAIPI acceleration and TGV reconstruction to achieve a ~9-minute protocol with 5 delays with 8 averages per delay. We tested the feasibility of this protocol on 19 pediatric subjects and found the proposed imaging protocol with TGV constrained reconstruction can improve the test-retest reliability of high-resolution 3D pCASL perfusion imaging in typically developing children compared to a standard segmented acquisition.

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