Abstract #2757

Measuring Microvascular Pulsatility with Short Bolus Duration (τ) VSASL

Conan Chen^1,2, Ryan A. Barnes^1,2, Eric C. Wong^1,3, Thomas T. Liu^1,3,4, and Divya S. Bolar¹

¹Center for fMRI, Department of Radiology, University of California San Diego, La Jolla, CA, United States, ²Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, United States, ³Department of Psychiatry, University of California San Diego, La Jolla, CA, United States, ⁴Department of Bioengineering, University of California San Diego, La Jolla, CA, United States

Synopsis

Keywords: Arterial spin labelling, Arterial spin labellingPulsatile blood flow has been linked to structural damage to the cerebral microvasculature. Previous methods have successfully measured pulsatility in the arteries, but few methods exist to target the microvasculature where the damage is occurring. In this current work, we present a simple theoretical model for CBF pulsatility, apply the model to experimental data acquired in human subjects, and report in vivo microvascular pulsatility using VSASL.

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