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Abstract #2759

Spatiotemporal redundancy based denoising method in arteprial spin labeling MRI: A ticket to free sensitivity improvement

Xinran Chen1, Liangjie Lin2, Zhiliang Wei3, Lin Chen1, and Zhong Chen1
1Department of electronic science, Xiamen University, Xiamen, China, 2Clinical & Technical Support, Philips Healthcare, Beijing, China, 3Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Arterial spin labelling, Data Processing, DenoisingArterial-spin-labeling (ASL) MRI has been widely used in neurological studies for investigating brain activity via focusing on regional perfusion differences. However, sensitivity is a general issue in ASL MRI to prevent the high-resolution comparisons of perfusion heterogeneity, which are associated with pathological process, or lead to prolonged scan time, which inhibits the temporal resolution in monitoring acute-stage perfusion changes (e.g., perfusion recovery after spontaneous resuscitation in cardiac arrest). Therefore, in this study, a post-processing method exploring spatiotemporal redundant information of ASL data is proposed to enhance the sensitivity without extending scan durations.

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