Keywords: Validation, Animals, Arterial input functions, small animals, spleen, liver
Accurate biomarker quantification is hindered in small animal MRI due to difficulties in reliably deriving arterial input functions (AIFs). This study provides a robust alternative to commonly used approaches by deriving AIFs from a simple, whole-body circulation model. This method is compared with individual and population spleen-derived AIFs by evaluating performance in gadoxetate DCE-MRI of the rat liver. Results demonstrated that the whole-body circulation model-derived AIF yields greater repeatability, reproducibility, and goodness-of-fit to observed data, indicating that it provides more accurate biomarker quantification than the individual or population spleen-derived AIFs.
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