Abstract #2766

MRI and Ultrasound of lower extremity subcutaneous adipose tissue: potential translational screening tools for lipedema

Yinan Zheng¹, John A. Beasley², Vanessa Crain², Shannon L. Taylor³, Michael D. Pridmore², Maria E. Garza^2,4, Sheau-Chiann Chen⁵, Aaron W. Aday⁶, Joshua A. Beckman⁶, Paula M.C. Donahue^7,8, Manus J. Donahue^4,9, and Rachelle L. Crescenzi^2,3

¹Vanderbilt University School of Medicine, Nashville, TN, United States, ²Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ³Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ⁴Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, ⁵Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States, ⁶Vanderbilt Translational and Clinical Cardiovascular Research Center, Cardiovascular Medicine Division, Vanderbilt University Medical Center, Nashville, TN, United States, ⁷Department of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, United States, ⁸Dayani Center for Health and Wellness, Vanderbilt University Medical Center, Nashville, TN, United States, ⁹Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: MSK, Screening, Translational StudiesLipedema is an underdiagnosed connective tissue disorder characterized by disproportionate subcutaneous adipose tissue (SAT) accumulation in the lower extremities. Lipedema is frequently misdiagnosed as obesity and objective diagnostic tools are lacking for lipedema. Patients with lipedema (n=22) and BMI-matched controls (n=7) underwent lower extremity MRI and ultrasound evaluations of SAT as potential diagnostic modalities. MRI and ultrasound measurement of SAT thickness yielded good concordance between modalities (Pearson’s r=0.95, reproducibility coefficient=3.3 mm), and demonstrated similar moderate effect sizes (Cohen’s d>0.5) for discriminating lipedema from controls. MRI and ultrasound are promising screening modalities for lipedema.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.