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Abstract #2768

Sodium 23Na-MRI reveals elevated sodium content in lower-extremity skin and adipose tissue in peripheral arterial disease

Michael Pridmore1,2, Emily Shardelow3, Shannon L. Taylor1,2,4, Adam Behroozian5, Manus J. Donahue6,7, Alex Sullivan3, Joshua A. Beckman8, and Rachelle Crescenzi1,2,4
1Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 2Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 3Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, United States, 4Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 5Cardiovascular Medicine, Scripps Memorial Hospital La Jolla, San Diego, CA, United States, 6Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 7Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 8Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: MSK, Atherosclerosis, Multi-Nuclear, Peripheral DiseasePeripheral artery disease (PAD) is an atherosclerotic occlusive disease that reduces lower-limb perfusion, causes ambulatory dysfunction, and leg pain. Sodium imaging (23Na-MRI) may reveal areas of increased tissue sodium deposition related to the mechanisms of PAD dysfunction. We found that patients with PAD showed increased tissue sodium content in skin, subcutaneous adipose tissue (SAT), and inter-muscular adipose tissue (IMAT) compared to controls. Participants with PAD had lower SAT volume and fat content, arguing against a positive relationship between fat as the mediator of increased tissue sodium. 23Na-MRI may inform PAD mechanisms and is being investigated in response to PAD therapies.

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