Abstract #2784

High Heterogeneity of White Matter Observed with Short TE Magnetic Resonance Elastography

Samuel Patz^1,2, W. Scott Hoge^3,4, Bin Deng^2,5, Lauren O'Donnell^1,2, Fan Zhang^1,2, Yanmei Tie^2,6, Emma Tinney⁷, Ralph Sinkus⁸, and Katherine M. Breedlove^1,2

¹Radiology, Brigham and Women's Hospital, Boston, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³SigProc Expert Solutions, Westwood, MA, United States, ⁴Imaginostics, Inc., Cambridge, MA, United States, ⁵Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ⁶Neurosurgery, Brigham and Women's Hospital, Boston, MA, United States, ⁷Psychology, Northeastern University, Boston, MA, United States, ⁸INSERM, Paris, France

Synopsis

Keywords: White Matter, Elastography, superficial white matter heterogeneity, myelin waterPrior MRE work in the brain has utilized long TE pulse sequences (spiral and EPI) and therefore has necessarily not observed the signal from short T2 components. In particular, the signal from water compartmentalized in myelin membranes and that is a sensitive measure of white matter structural integrity, has been missed. Here we demonstrate high heterogeneity of the shear stiffness within the superficial white matter when utilizing MRE sequences with a short (10ms) TE.

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