Abstract #2785

Longitudinal change of white matter-specific brain age is associated with Alzheimer's disease-related regional atrophy

Chang-Le Chen¹, Jinghang Li¹, Linghai Wang¹, Noah Schweitzer¹, Dana Tudorascu^2,3, Howard Aizenstein^1,2, and Minjie Wu^1,2

¹Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, ²Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States, ³Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, United States

Synopsis

Keywords: White Matter, Aging, brain ageThe white matter (WM) network integrity is assumed to associate with Alzheimer's disease (AD)-related gray matter (GM) atrophy. To investigate this hypothesis, we estimated WM-specific brain age to quantify WM integrity and calculated twelve AD-related GM signatures in a longitudinal cognitively normal cohort. We identified that the change rate of WM brain age was significantly correlated with the left hippocampal and amygdala volumetric changes; that is, the accelerated aging in WM was associated with the more atrophic GM volumes. This result suggested that changes of structural network characterized by brain age metrics can reflect the alteration of AD-related GM signatures.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.