Abstract #2794

Individual-specific TBSS of diffusion and relaxometry measures reveal differences of global white matter in autistic individuals

Jose Guerrero-Gonzalez¹, Olivia Surgent², Nagesh Adluru³, Gregory Kirk³, Steven Kecskemeti³, Douglas Dean III¹, Brittany Travers⁴, and Andrew Alexander¹

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Neuroscience Training Program, Waisman Center, University of Wisconsin - Madison, Madison, WI, United States, ³Waisman Center, University of Wisconsin - Madison, Madison, WI, United States, ⁴Kinesiology, University of Wisconsin - Madison, Madison, WI, United States

Synopsis

Keywords: White Matter, Diffusion/other diffusion imaging techniques, AutismFor neurological conditions that effect brain regions differently across individuals, quantitative neuroimaging-based metrics of individual deviation may be more informative in characterizing neuroanatomical variation including normal from abnormal variations than commonly used group-wise analyses. This work uses a joint analysis of iTBSS (individual-specific Tract-Based Spatial Statistics) of multiple neuroimaging measures from diffusion and relaxometry to better characterize differences between autistic and non-autistic individuals.

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