Abstract #2795

Measures of vascular function influence the number and volume of white matter hyperintensities in older, hypertensive subjects

Andrew Crofts¹, Jessica Steventon², Joseph Whittaker³, Marcello Venzi³, Hannah Chandler⁴, Michael Germuska⁴, Mahfoudha Al Shezawi⁵, Eric Stohr⁵, Chris Pugh⁵, Barry McDonnell⁵, and Kevin Murphy³

¹National Institute for Quantum and Radiological Science and Technology, Chiba, Japan, ²CUBRIC, School of Medicine, Cardiff University, Cardiff, United Kingdom, ³CUBRIC, School of Physica and Astronomy, Cardiff University, Cardiff, United Kingdom, ⁴CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, ⁵Cardiff Metropolitan University, Cardiff, United Kingdom

Synopsis

Keywords: White Matter, AgingDamage to the deep white matter of the brain has been shown to correlate with hypertension and advanced age. However, the changes in the cerebral microvasculature that cause white matter lesions are unclear. Increased blood pressure causes morphological changes in cerebral vessels, and impaired vascular function and neurovascular coupling is a potential factor. Here, we demonstrate that age, central pulse pressure, and dual-echo MRI measures of CBF, CVR, CMRO2 and OEF influence the number and volume of white matter hyperintensities.

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