Abstract #2799

Radiation Dependent Demyelination in Normal Appearing White Matter in Glioma Patients, Determined Using Quantitative MRI

Anna Ljusberg^1,2, Ida Blystad^2,3, Peter Lundberg^1,2, Emelie Adolfsson¹, and Anders Tisell^1,2

¹Department of Medical Radiation Physics, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden, ²Center for Medical Image science and Visualization (CMIV), Linköping University, Linköping, Sweden, ³Department of Radiology in Linköping, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden

Synopsis

Keywords: White Matter, RadiotherapyAdding quantitative MRI to existing examinations for patients with malignant glioma is valuable for observing changes in tissue specific parameters such as R₁, R₂, proton density and myelin concentration. Changes observed in this study, with a decrease of myelin concentration and increase of proton density, in normal appearing white matter can be interpreted as a demyelination caused by radiation therapy. For low doses (<30 Gy), but not for high (>30 Gy) the myelin concentration returns to baseline.

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