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Abstract #2800

Macromolecular proton fraction as a biomarker of early myelination: ultrastructural and immunochemical validation in a rabbit model

Alexander Drobyshevsky1, Daniil Aksenov1, and Vasiliy Yarnykh2
1NorthShore University HealthSystems, Evanston, IL, United States, 2Radiology, University of Washington, Seattle, WA, United States

Synopsis

Keywords: White Matter, Quantitative Imaging, myelinUltrastructural and immunochemical methods of myelin quantification were applied to validate a model-based MRI techniques, macromolecular proton fraction mapping (MPF), during early development in major white matter tracts and cerebral cortex in rabbits. MPF trajectories were in general agreement with levels of myelination by histology and accurately reflected differential rate of development between white matter tracts and cortical regions.

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