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Abstract #2801

Comparison of machine learning models for discriminating obsessive-compulsive disorder based on automated fiber quantification

Suming Zhang1, Xuan Bu2, Lingxiao Cao1, Hailong Li1, Kaili Liang1, Zilin Zhou1, Yingxue Gao1, Lianqing Zhang1, Bin Li3, and Xiaoqi Huang1
1Huaxi MR Research Center(HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China, 3Mental Health Center, West China Hospital of Sichuan University, Chengdu, China

Synopsis

Keywords: White Matter, Diffusion Tensor ImagingIn this study, we compared the classification performance of different machine learning models for discriminating OCD patients based on DTI tractography. Firstly, we extracted DTI metrics and tract volumes as features. Following feature selection, four machine learning models were performed for classification. Finally, a novel SHapley Additive exPlanations (SHAP) analysis was used to intepret the value of importance for each feature. We found that XGBoost exhibited the best classification performance among the four models. The model explanation by SHAP suggested that the volume of callosal orbital frontal tract was the most important factor in differentiating OCD from healthy controls.

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