Abstract #2803
Myelin quantification: is it possible to obtain comparable g-ratio maps from different acquisition techniques?
Marta Gaviraghi1, Eleonora Lupi1, Simone Rancati2, Fulvia Palesi1, Francesco Grussu3,4, Marco Battiston3, Carmen Tur3,4, Alberto Calvi3, Sara Collorone3, Antonio Ricciardi3, Ferran Prados3,5,6, Baris Kanber3,7, Egidio D'Angelo1,8, Rebecca S. Samson3, and Claudia A. M. Gandini Wheeler-Kingshott1,3,8
1Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 2Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy, 3NMR Research Unit, Department of Neuroinflammation, Queen Square Multiple Sclerosis Centre, UCL Queen Square Institute of Neurology, University College London (UCL), London, United Kingdom, 4Neurology-Neuroimmunology Department Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, 5Department of Medical Physics and Biomedical Engineering, Centre for Medical Image Computing (CMIC), University College London, London, United Kingdom, 6E-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain, 7Department of Medical Physics and Biomedical Engineering, Centre for Medical Image Computing (CMIC), University College London, London, Italy, 8Brain Connectivity Centre, IRCCS Mondino Foundation, Pavia, Italy
Synopsis
Keywords: White Matter, Multi-Contrast, MyelinQuantifying myelin in vivo with MRI is useful for studying multiple sclerosis by calculating the g-ratio. To estimate the g-ratio, special sequences often must be set. We have developed a preliminary method for calculating g-ratio from clinical images i.e. T1w and T2w. We then compared three methods to obtain the g-ratio: from quantitative Magnetization Transfer (qMT) (gold standard), from Macromolecular Tissue Volume (MTV) and from T1w/T2w. The MTV (g_MTV) and T1w/T2w (g_T1wT2w) g-ratios were different from the qMT g-ratio (g_qMT). g_MTV flattens differences between healthy and pathological subjects whereas g_T1wT2w has the same median trend as g_qMT.
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