Abstract #2805

Non-invasive MRI of Blood-Cerebrospinal-Fluid-Barrier Function: A Novel Functional Biomarker of Alzheimer's Disease Pathology

Charith Perera¹, Renata Cruz², Noam Shemesh², David L. Thomas^3,4,5, Jack Wells¹, and Andrada Ianus²

¹UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom, ²Champalimaud Foundation, Lisbon, Portugal, ³Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation,, UCL Queen Square Institute of Neurology, London, United Kingdom, ⁴Dementia Research Centre, UCL Queen Square Institute of Neurology, London, United Kingdom, ⁵Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, London, United Kingdom

Synopsis

Keywords: Alzheimer's Disease, Arterial spin labellingAlzheimer’s disease (AD) is characterised by many pathophysiological changes, such as the accumulation of amyloid-β. The clearing of detrimental agents, including amyloid-β proteins, from brain tissue is linked to the function of choroid plexus (CP) or blood-cerebrospinal fluid barrier (BCSFB).This study investigates for the first time BCSFB function using non-invasive ASL-based methods in a mouse model of AD. Significantly higher values of total BCSFB-mediated water delivery in AD mice relative to controls were observed as early as 8 weeks of age, and a possible (though currently non-significant) correlation with behavioural tests was identified.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.