Keywords: Dementia, fMRI (resting state)In this study, functional and structural changes in visual network (VN) of type 2 diabetes mellitus (T2DM) were investigated using multimodal magnetic resonance imaging. We explored degree centrality (DC), amplitude of low frequency fluctuation (ALFF), fractional anisotropy (FA), DC-FA and ALFF-FA in VN. Compared with healthy controls, deteriorated DC, ALFF and DC-FA coefficients in VN were observed in T2DM. These indicators showed positive correlations with cognitive function in T2DM, especially memory and executive function. Functional-structural decoupling may be a potential image biomarker of cognitive function change in T2DM.
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