Abstract #2809

**Microstructural neurodegeneration of the entorhinal-hippocampus pathway in preclinical Alzheimer’s disease: ex vivo 11.7T MRI and histology**

Yuto Uchida¹, Kengo Onda¹, Jill Chotiyanonta¹, Zhipeng Hou¹, Juan Troncoso², Susumu Mori¹, and Kenichi Oishi¹

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Alzheimer's Disease, MicrostructureConventional neuroimaging biomarkers for the neurodegeneration of Alzheimer’s disease (AD) are not sensitive enough to detect neurodegenerative alterations in preclinical AD individuals. We aimed to examine microstructural neurodegeneration of the entorhinal-hippocampus pathway during the pathological process of AD. Our ex vivo comparative study of 11.7T MRI and histology successfully visualized microstructural neurodegeneration of the entorhinal-hippocampus pathway in preclinical AD brain tissues. In a future study, we aim to translate the findings from ex vivo 11.7T MRI and histology into in vivo MRI clinical research for preclinical AD individuals.

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