Abstract #2814

Comparability of mcTFI QSM and 2D GRE CMB Detection: Implications for for Alzheimer’s Anti-Amyloid Therapy

Nikita Seth¹, Geunwon Kim², Magdy Selim³, Ajith J Thomas⁴, Aristotelis Filippidis⁵, Yan Wen⁶, Pascal Spincemaille⁷, Yi Wang⁷, and Salil Soman¹

¹Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ²Atrius Health, Boston, MA, United States, ³Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ⁴Department of Neurological Surgery, Cooper University Health Care, Cooper Medical School of Rowan University, Camden, NJ, United States, ⁵Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ⁶GE Healthcare, New York, NY, United States, ⁷Department of Radiology, Weill Cornell Medicine, New York, NY, United States

Synopsis

Keywords: Alzheimer's Disease, Quantitative Susceptibility mapping, CMB, 2D GRE, mcTFI, Anti-amyloid therapyCerebral microbleeds/microhemorrhages (CMB) are used for risk stratification, including for the hemorrhagic complication ARIA-H of Alzheimer’s anti-amyloid therapy. For AD, risk information is based on many trials using 2DGRE technique, which is MRI field and parameter dependent. The use of techniques that better distinguish CMB mimics, like calcifications, is limited by an unclear relationship to 2D GRE CMB depiction. In this study we found the number of CMB candidate lesions between 2D GRE and mcTFI QSM obtained during the same scan session highly correlated, suggesting mcTFI could be used in the management of pathologies evaluating presence and number of CMBs.

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