Abstract #2815

Ultra-High Resolution QSM of the Brain Iron Metabolism in the Cognitively Declined Adults at 7T MRI

Akbar Alipour¹, Pinar S Ozbay², Ameen Alqadi¹, Mackenzie Langan¹, Mehmet Kurt³, Trey Hedden ⁴, Bradley N Delman¹, and Priti Balchandani¹

¹Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Biomedical Engineering, Boğaziçi University, Istanbul, Turkey, ³Department of Mechanical Engineering, University of Washington, Seattle, WA, United States, ⁴Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

Synopsis

Keywords: Alzheimer's Disease, Quantitative Susceptibility mappingDetection of iron aggregations associated with beta-amyloid in Alzheimer’s disease would help to understand the related pathophysiology in these cohorts. Aggregations of iron associated beta-amyloid should increase electron density and induce notable changes in local susceptibility value. With higher susceptibility at ultra-high field strengths, induced iron susceptibility is large enough to generate contrast relative to surrounding normal tissues that can be visualized by quantitative susceptibility techniques at 7 Tesla MRI. In this study, we used 7T MRI to analyze the iron-related pathologic markers in Alzheimer patients using the quantitative susceptibility mapping technique.

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