Abstract #2817

Evaluation of relationship between trigeminal nerve stimulation and hemodynamics using 4D-Flow MRI: A pilot study in swine model

Mu-Lan Jen¹, Nishant Verma^2,3, Kevin P Cheng^2,3, Robert Moskwa¹, Grant S Roberts¹, Maria Laluzerne^2,3, Jennifer Frank^2,3, Justin Williams^2,3, Wally Block¹, Kip Ludwig^2,3,4, and Kevin M Johnson^1,5

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ³Wisconsin Institute for Translational Neuroengineering (WITNe) – Madison, Madison, WI, United States, ⁴Neurosurgery, University of Wisconsin-Madison, Madison, WI, United States, ⁵Radiology, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Alzheimer's Disease, Velocity & FlowThis study utilizes 4D-Flow imaging to evaluate hemodynamic alterations during the period of nerve stimulation and investigates cerebral blood flow changes modulated by using 4D-Flow MRI in large animal models. Preliminary results showed cerebral blood flow increases while flow pulsatility decreases with the electrical stimulation of trigeminal nerves. This effect from neuromodulation is on the contrary to the hemodynamic alterations with aging and AD progression, which implies the potential of neuromodulation as an alternative treatment approach in repairing glymphatic system function.

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