Abstract #2818

Comparison of MR Spectroscopy of Probable Alzheimer’s Disease and Symptoms of Chronic Traumatic Encephalopathy

Jessica J. Chen¹, Michael L. Alosco², Huijun Liao¹, Inga K. Koerte^3,4, Martha E. Shenton³, Robert A. Stern⁵, and Alexander P. Lin¹

¹Center for Clinical Spectroscopy,Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, ²Boston University School of Medicine, Department of Neurology, Boston University Alzheimer's Disease and CTE Centers, Boston, MA, United States, ³Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, ⁴Department of Child and Adolescent Psychiatry, Psychosomatic, and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany, ⁵Neurosurgery, and Anatomy & Neurobiology, Departments of Neurology, Boston University Alzheimer’s Disease and CTE Center, Boston, MA, United States

Synopsis

Keywords: Alzheimer's Disease, Spectroscopy, traumatic brain injury, chronic traumatic encephalopathyChronic traumatic encephalopathy (CTE) is widely found in individuals exposed to repetitive head impacts (RHI) in organized contact sports, such as football. Previous findings have determined that there is a distinct deposition of phosphorylated tau (p-tau) in its neuropathology compared to other tauopathies, including Alzheimer’s disease. However, there is a lack of diagnostic criteria that examine later-life neurochemical changes due to long-term neurologic consequences to RHI. This study uses magnetic resonance spectroscopy (MRS) to compare neurochemical markers between participants with probable Alzheimer’s disease and symptomatic chronic traumatic encephalopathy in relation to healthy controls.

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