Abstract #2819

Discovering the Metabolomic Relationships between Lung Cancer and Alzheimer’s Disease using Nuclear Magnetic Resonance Spectroscopy

Leo Ling Cheng^1,2, Zuzanna Kobus^1,2,3, Marta Kobus^1,2,4, Li Su⁵, and David C. Christiani⁵

¹Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴Department of Radiation Oncology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁵Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States

Synopsis

Keywords: Alzheimer's Disease, Spectroscopy, MetabolomicsHerein, we report our preliminary data on metabolomic associations between human lung cancer (LuCa) and Alzheimer’s disease (AD) measured from serum samples using high resolution magic angle spinning (HRMAS) MRS. The current project’s objective is to establish MRS-based tissue pathology-guided serum metabolomic profiles for matched LuCa patients, with and without AD, by comparing serum profiles measured from matched healthy controls. Initial results demonstrate the feasibility of HRMAS MRS for LuCa-AD metabolomic mechanisms investigation. Our findings serve as a foundation for innovative future diagnostic and treatment studies.

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