Abstract #2820

4D flow MRI reveals cerebrovascular changes in early Alzheimer’s disease

Ayah Elsayed¹, Tracy Melzer^2,3,4, Lynette Tippett⁵, and Catherine Morgan^5,6

¹Faculty of Health & Environmental Studies, Auckland University of Technology, Auckland, New Zealand, ²Department of Medicine, University of Otago, Christchurch, New Zealand, ³NZ Brain Research Institute, Christchurch, New Zealand, ⁴School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand, ⁵Department of Psychology, University of Auckland, Auckland, New Zealand, ⁶Centre for Advanced MRI, University of Auckland, Auckland, New Zealand

Synopsis

Keywords: Alzheimer's Disease, Velocity & Flow

Currently 50 million people suffer from Alzheimer’s disease (AD), the most common form of dementia, yet treatment options are limited. A growing focus on the contribution of cerebrovascular (CV) health presents new possible targets for treatment. We investigated novel CV imaging markers using 4D flow MRI in a total of 43 participants with mild cognitive impairment, early AD and controls. Both the MCI and AD group had significantly reduced mean blood flow in the larger vessels of the Circle of Willis. A significantly increased pulsatility index (indicative of poorer vessel compliance) was found in the AD group compared to controls.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.