Abstract #2821

Identifying fiber tracts strategic for cognitive impairments in cerebral small vessel disease with harmonized diffusion MRI

Peiyu Huang¹, Carolina Canelas Valentim², Geert-Jan Biessels², Christopher Chen³, Anna Dewenter⁴, Marco Duering^4,5, Saima Hilal³, Huiberdina L Koek⁶, Anna Kopczak⁴, Bonnie Yin Ka Lam⁷, Alexander Leemans⁸, Vincent Mok⁷, Laurien Onkenhout², Hilde van den Brink², and Alberto De Luca⁹

¹Department of Radiology, Zheijang University School of Medicine,, Hangzhou, China, ²UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands, ³Aging and Cognition Center, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, ⁴Institute for Stroke and Dementia Research, LMU Munich, Munich, Germany, ⁵Medical Image Analysis Center, University of Basel, Basel, Switzerland, ⁶Department of Geriatric Medicine, University Medical Center Utrecht, Utrecht, Netherlands, ⁷Division Neurology, The Chinese University of Hong Kong, Hong Kong, China, ⁸Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, ⁹Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, Netherlands

Synopsis

Keywords: Dementia, White MatterSmall vessel disease (SVD) is a worldwide leading cause of dementia. Damage to white matter tracts is a key mechanism through which SVD impacts cognition. In this work, we leverage a large multicenter dataset of patients with SVD to investigate which white matter tracts are strategic in SVD, that is, robustly associated with cognitive decline. Our early results show that the corpus callosum, superior longitudinal fasciculus and thalamo parietal tracts were the most associated to processing speed, verbal memory and executive function, respectively. Tract-based measures explained additional variance (2-5%) as compared to whole brain measures.

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