Abstract #2824

SWI and MRSI Unite! Metabolic Insights into Iron Deposition in Relapsing-Remitting MS via 7T Magnetic Resonance Spectroscopic Imaging

Alexandra Lipka¹, Wolfgang Bogner¹, Assunta Dal-Bianco², Gilbert Hangel^1,3, Paulus Rommer², Bernhard Strasser¹, Stanislav Motyka¹, Lukas Hingerl¹, Thomas Berger², Fritz Leutmezer², Stephan Gruber¹, Siegfried Trattnig^1,4, and Eva Niess¹

¹Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, High Field MR Centre, Vienna, Austria, ²Medical University of Vienna, Department of Neurology, Vienna, Austria, ³Medical University of Vienna, Department of Neurosurgery, Vienna, Austria, ⁴Karl Landsteiner Institute for Clinical Molecular MRI in Musculoskeletal System, Vienna, Austria

Synopsis

Keywords: Multiple Sclerosis, Multiple SclerosisBesides clinical examination, conventional T1/T2-weighted magnetic resonance imaging (cMRI) is the method of choice for diagnosis and treatment monitoring of Multiple Sclerosis (MS). In contrast to cMRI, which - in MS - can only depict the severity of irreversible tissue damage and is not able to explain underlying pathological processes, MR Spectroscopic Imaging (MRSI) can detect pathologies on a biochemical level, while Susceptibility Weighted Imaging (SWI) provides information about iron deposition. In 31 relapsing-remitting (RRMS) patients, we investigate - via ultra-high resolution FID-MRSI at 7T - metabolic characteristics of different types of iron accumulation and the metabolic distribution within lesions and their vicinity.

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