Meeting Banner
Abstract #2827

7-Tesla in vivo 1H-MRS-measured prefrontal glutathione increases during oral fumarate therapy in relapsing-remitting multiple sclerosis

Kelley M. Swanberg1, Hetty Prinsen2, Daniel Pelletier2,3, and Christoph Juchem1,2,4,5
1Biomedical Engineering, Columbia University, New York, NY, United States, 2Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, United States, 3Neurology, University of Southern California Keck School of Medicine, Los Angeles, CA, United States, 4Neurology, Yale University School of Medicine, New Haven, CT, United States, 5Radiology, Columbia University Irving Medical Center, New York, NY, United States

Synopsis

Keywords: Multiple Sclerosis, Spectroscopy, dimethyl fumarate, glutathione, oxidative stressMultiple sclerosis (MS) is an autoimmune disease that damages the central nervous system. Oxidative stress, thought to play a role in MS-related pathophysiology, can be modulated in the cell by endogenous antioxidants such as glutathione (GSH), hypothesized to participate in the therapeutic effect of MS disease-modifying therapy dimethyl fumarate. We used proton magnetic resonance spectroscopy (1H MRS) to measure in vivo cortical glutathione concentrations in individuals with relapsing-remitting multiple sclerosis (RR-MS) before and during 12 months of dimethyl fumarate therapy and observed a significant positive effect of time on prefrontal cortex glutathione. No such change was shown in healthy controls.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords