Abstract #2828

Time-dependent Diffusion in Acute and Chronic Plaques of Multiple Sclerosis Investigated with Oscillating-gradient Spin-echo.

Tomoko Maekawa¹, Masaaki Hori^1,2, Katsutoshi Murata³, Kouhei Kamiya^1,2, Christina Andica^1,4, Akifumi Hagiwara¹, Shohei Fujita^1,5, Koji Kamagata¹, Akihiko Wada¹, and Shigeki Aoki¹

¹Juntendo University School of Medicine, Tokyo, Japan, ²Toho University Omori Medical Center, Tokyo, Japan, ³Siemens Healthcare K.K., Tokyo, Japan, ⁴Faculty of Health Data Science, Juntendo University, Chiba, Japan, ⁵The University of Tokyo, Tokyo, Japan

Synopsis

Keywords: Multiple Sclerosis, Diffusion/other diffusion imaging techniques, MicrostructureThe purpose of our study was to investigate the utility of changes in diffusivity between short and long diffusion time in evaluating acute and chronic plaques of multiple sclerosis. Chronic plaques showed weak diffusion time-dependence with diffusion times between 6.5 ms and 35.2 ms. The differences in diffusion time-dependence were attributed to the internal structure of plaques. DWI with a short diffusion time may provide additional information about the microstructure of MS plaques.

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