Keywords: Multiple Sclerosis, Gray MatterThis study investigated the shape changes in the subcortical structure of patients with multiple sclerosis (PwMS) and how they are associated with MS-related fatigue. Surface-based vertex analysis was performed on 25 fatigued RRMS (F-MS), 25 non-fatigued RRMS (NF-MS), and 40 healthy controls (HCs). Compared to HCs, PwMS showed regional shape contractions in the areas of bilateral thalamus. The morphological changes in the bilateral thalamus occur only on the side closest to the ventricles. Compared to the NF-MS subgroup, F-MS patients showed regional surface atrophy in the areas of left caudate nucleus, which was negatively correlated with the severity of fatigue.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords