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Abstract #2832

Association of subcortical structural shapes with fatigue in Multiple Sclerosis.

Yujing Li1,2, Tingli Yang3, Min Li3, Rui Wang3, Xinying Ren3, Diaohan Xiong3, Kai Ai4, and Jing Zhang3
1Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China, 2Second Clinical School, Lanzhou University, Lanzhou, China, 3Lanzhou University Second Hospital, Lanzhou, China, 4Philips Healthcare, Xi’an, China

Synopsis

Keywords: Multiple Sclerosis, Gray MatterThis study investigated the shape changes in the subcortical structure of patients with multiple sclerosis (PwMS) and how they are associated with MS-related fatigue. Surface-based vertex analysis was performed on 25 fatigued RRMS (F-MS), 25 non-fatigued RRMS (NF-MS), and 40 healthy controls (HCs). Compared to HCs, PwMS showed regional shape contractions in the areas of bilateral thalamus. The morphological changes in the bilateral thalamus occur only on the side closest to the ventricles. Compared to the NF-MS subgroup, F-MS patients showed regional surface atrophy in the areas of left caudate nucleus, which was negatively correlated with the severity of fatigue.

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