Abstract #2834

A pilot in vivo study of the sciatic nerve in multiple sclerosis using quantitative magnetic resonance imaging

Ratthaporn Boonsuth^1,2, Marco Battiston¹, Rebecca S. Samson¹, Alberto Calvi^1,3, Claudia A. M. Gandini Wheeler-Kingshott^1,4,5, and Marios C. Yiannakas¹

¹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ²Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand, ³Center of Neuroimmunology, Laboratory of Advanced Imaging in Neuroimmunological Diseases; Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ⁴Brain Connectivity Research Centre, IRCCS Mondino Foundation, Pavia, Italy, ⁵Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy

Synopsis

Keywords: Multiple Sclerosis, Quantitative Imaging, Nerves, Multimodal, NeurographyThe peripheral nervous system is not routinely examined objectively in multiple sclerosis (MS), despite evidence from neuropathology that demonstrates its implication. In this pilot in vivo study, the sciatic nerve was examined using multi-shell diffusion-weighted imaging, quantitative magnetisation transfer and T1 relaxometry to investigate whether pathological neural tissue damage could be detected in people with relapsing-remitting MS as compared to healthy controls.

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