Abstract #2835

Lesional and non-lesional cortical integrity in cognitive networks are linked to cognitive impairment in multiple sclerosis.

Eva A. Krijnen^1,2, Albulena Bajrami^1,3, Tommy A.A. Broeders¹, Samantha Noteboom¹, Piet M. Bouman¹, Frederik Barkhof^4,5, Bernard M.J. Uitdehaag⁶, Eric C. Klawiter², Ismail Koubiyr¹, and Menno M. Schoonheim¹

¹MS Center Amsterdam, Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, Netherlands, ²Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ³Multiple Sclerosis Specialist Center, Neurology B, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy, ⁴MS Center Amsterdam, Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, Netherlands, ⁵Institutes of Neurology and Healthcare Engineering, University College London, London, United Kingdom, ⁶MS Center Amsterdam, Neurology, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, Netherlands

Synopsis

Keywords: Multiple Sclerosis, Gray Matter, Diffusion/Other Diffusion Imaging TechniquesCognitive functioning in people with multiple sclerosis (MS) is strongly related to cortical lesions (CLs), although the severity of demyelination remains difficult to assess in-vivo. In addition, how the pathological microstructural changes in normal-appearing gray matter relate to cognition also remains unclear. This study assessed how microstructural integrity (based on diffusion MRI) in CLs and normal-appearing cortex relates to cognition in MS. Microstructural integrity changes were most evident in cognitively-impaired MS, especially in the normal-appearing cortex. Regionally, damage was especially related to cognition within cognitive functional networks such as the ventral attention network.

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