Abstract #2836

Characterization of Paramagnetic Rim Lesions using quantitative and semi-quantitative MRI modalities

Agnese Tamanti¹, Annalisa Colombi¹, Angela Peloso¹, Nicola Serafin¹, Valentina Camera¹, Francesca Benedetta Pizzini², Marco Castellaro³, and Massimiliano Calabrese²

¹Department of Neurosciences, Biomedicine and Movement sciences, University of Verona, Verona, Italy, ²Neuroradiology Unit, Department of Diagnostics and Pathology, University of Verona, Verona, Italy, ³Department of Information Engineering, University of Padova, Padova, Italy

Synopsis

Keywords: Multiple Sclerosis, Multi-Contrast, paramagnetic rim lesionsChronic active lesions have been recently investigated in multiple sclerosis (MS) and associated with the detection of paramagnetic rims on susceptibility-based MRI images (filtered phase and quantitative susceptibility mapping). Quantitative MRI approaches have the potential to reveal the degree of tissue damage in paramagnetic rim lesions. In this study a significant increase in T2* relaxation time and Quantitative Susceptibility Mapping (QSM) as well as a decrease in Magnetization Transfer Ratio (MTR) and Magnetization Transfer Saturation (MTSat) was revealed in PRL+ lesions compared to PRL-, thus supporting the use of these MRI metrics to detect tissue damage associated with chronic activity.

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