Abstract #2839

Time- and Signal-Efficient 3T Ultra-High-Resolution Imaging of the Ex Vivo Cerebellum and Entire Human Brain

Matthias Weigel^1,2,3, Peter Dechent⁴, Riccardo Galbusera^1,2, Erik Bahn⁵, Ludwig Kappos^1,2, Wolfgang Brück⁵, Christine Stadelmann⁵, and Cristina Granziera^1,2

¹Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland, ²Neurological Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland, ³Division of Radiological Physics, Dept. of Radiology, University Hospital Basel, Basel, Switzerland, ⁴MR-Research in Neurosciences, Department of Cognitive Neurology, University Medical Center Göttingen, Göttingen, Germany, ⁵Institute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany

Synopsis

Keywords: Multiple Sclerosis, Ex-Vivo ApplicationsEx Vivo MRI of the entire human brain facilitates new and fascinating insights into cerebral and cerebellar morphology and pathology. One key factor for achieving ultra-high spatial resolutions is a signal- and time-efficient MRI sequence, particularly, at 3T field strength. Though counterintuitive at first notion, we suggest a “slow” balanced steady-state free precession (bSSFP) approach with phase-cycling and very low receiver bandwidth (“LoBa-bSSFP”) as a highly signal- and time-efficient scheme for ex vivo acquisitions. LoBa-bSSFP can support spatial resolutions as high as 98-microns isotropic for covering the entire cerebellum on a common 3T MR system.

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