Abstract #2840

Assessment of multiple sclerosis pathology with quantitative magnetic resonance imaging

Sarah Schlaeger¹, Mark Mühlau², Guillaume Gilbert³, Irene Vavasour⁴, Thomas Amthor⁵, Mariya Doneva⁵, Aurore Menegaux¹, Markus Lauerer², Viola Pongratz², Claus Zimmer¹, Benedikt Wiestler¹, Christine Preibisch^1,2, Jan Kirschke¹, and Ronja C. Berg^1,2

¹Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, ²Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, ³MR Clinical Science, Philips Healthcare, Mississauga, ON, Canada, ⁴Department of Radiology, University of British Columbia, Vancouver, BC, Canada, ⁵Philips Research Europe, Hamburg, Germany

Synopsis

Keywords: Multiple Sclerosis, BrainQuantitative MRI in patients with multiple sclerosis (MS) allows for the objective identification of even subtle pathological changes in lesional, perilesional, NAGM, and NAWM tissue. Routine clinical scan protocols need to be tailored to the most diagnostically relevant MR biomarkers, however, to date only a few studies have investigated the particular diagnostic sensitivity of different MR biomarkers to different structural alterations of brain tissue affected by MS. Therefore, we studied 13 MS patients and 14 healthy controls using multiparametric, quantitative MR: we evaluated and compared the ability of nine different MR biomarkers to detect and characterize MS pathology.

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