Abstract #2847

The abnormal functional connectivity of the locus coeruleus can classify migraine without aura patients

Xiaozheng Liu¹, Jinming Chen², Keyang Chen¹, Kun Liu¹, Xi Zhang³, Lipeng Dong², han lu⁴, Yan Li¹, Zhihong Wang⁵, and Yungang Cao¹

¹The Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, China, ²The Hebei General Hospital, Shijiazhuang, China, ³Xingtai people's Hospital, Xingtai, China, ⁴Philips Healthcare, Shanghai, China, Shanghai, China, ⁵The Second Affiliated hospital, Hebei Medical University, Shijiazhuang, China

Synopsis

Keywords: Brain Connectivity, Nervous system, migraineBlood flow to the brainstem region is increased as a hypothesis for migraine. Locus coeruleus (LC) is the main noradrenergic nucleus in the brainstem. However, the functional characteristics of LC in migraine without aura (MwoA) patients are not currently known. Our results demonstrated that patients with MwoA exhibited significant LC FC differences in the brain areas associated with visual and cognitive function. Understanding the changes in the LC brain network in MwoA patients can provide us with new ideas to understand the pathological mechanisms of MwoA.

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