Keywords: Brain Connectivity, Multiple SclerosisIn this study, we explored hippocampal static and time-varying functional connectivity and its association with cognition in patients with multiple sclerosis. We found decreased static and time-varying connectivity of the hippocampus with temporo-parietal regions, and increased connectivity of the hippocampus with pre- and postcentral gyri, inferior temporal gyrus, precuneus and frontal regions. Better visuospatial and verbal memory were associated with higher hippocampal time-varying connectivity with precentral and inferior temporal gyri, while better attention scores were associated with higher hippocampal time-varying connectivity with the superior frontal cortex.
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