Abstract #2849

Disrupted topological organization of hubs in Parkinson’s disease patients with freezing of gait.

Karthik R Sreenivasan¹, Ece Bayram², Xiaowei Zhuang¹, Jason Longhurst³, Zhengshi Yang¹, Dietmar Cordes¹, Aaron Ritter⁴, Jessica Caldwell¹, Jeffrey L Cummings⁵, Zoltan Mari¹, Irene Litvan², Natividad Stover⁶, Talene Yacoubian⁶, Brent Bluett⁷, and Virendra Mishra^1,8

¹Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, ²Department of Neurosciences, University of California San Diego, La Jolla, CA, United States, ³Department of Physical Therapy and Athletic Training, Saint Louis University, St. Louis, MO, United States, ⁴Memory & Cognitive Disorders Program Hoag, Pickup Family Neurosciences Institute, Newport Beach, CA, United States, ⁵Chambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, School of Integrated Health Sciences, University of Nevada, Las Vegas, NV, United States, ⁶Department of Neurology, The University of Alabama at Birmingham, Birmingham, AL, United States, ⁷Central California Movement Disorders, Pismo Beach, CA, United States, ⁸Department of Radiology, The University of Alabama at Birmingham, Birmingham, AL, United States

Synopsis

Keywords: Brain Connectivity, Parkinson's DiseaseNeuroimaging studies, including resting-state functional MRI (rs-fMRI), have implicated altered resting-state functional connectivity (rs-FC) in PD patients with freezing of gait (PD-FOG) and showed that the disruption of connectivity between the resting state networks (RSNs) was correlated with FOG. However, the network organization in PD-FOG remains poorly understood. In this study, we use rs-fMRI data and graph theoretical approaches to explore the reorganization of functional networks in PD-FOG. The results of our study suggest that there is a substantial reorganization of regional brain hubs and disruption in the higher-order functional network topology in PD-FOG participants compared to PD-nFOG.

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