Keywords: Brain Connectivity, Diabetes, regional homogeneityTo further investigate the changes in brain function of type 2 diabetes we prospectively enrolled 38 patients clinically diagnosed with T2DM and 24 age-matched healthy controls and underwent blood oxygen level-dependent fMRI scans. The image data was processed to obtain regional homogeneity values and compared by two sample t test. Results found that the local synchronization of spontaneous neural activity of the supramarginal gyrus in patients with T2DM was abnormal and correlated with cognitive function, which may be involved in the pathophysiological mechanism of T2DM.
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