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Abstract #2853

Altered dynamic effective connectivity of the default mode network in T2DM

xu kun1, wang jun2, and zhang jing3
1medical, lanzhou unversity, lanzhou, China, 2lanzhou university, lanzhou, China, 3lanzhou university second hospital, lanzhou, China

Synopsis

Keywords: Brain Connectivity, Brain ConnectivityType 2 diabetes (T2DM) as one of the risk factors for developing Alzheimer's, however, the underlying pathogenesis of cognitive impairment in patients with T2DM was still unknown. our study combined the method of sliding-window approach and Granger causality analysis and found decreased dynamic effective connectivity (DEC) in T2DM compared with healthy people, and the decrease was associated with abnormal blood glucose level.

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