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Abstract #2854

Altered functional hubs and connectivity in type 2 diabetes mellitus with and without mild cognitive impairment

Yang Huang1, Dongsheng Zhang1, Xin Zhang1, Kai Ai2, Xiaoyan Lei1, and Xiaoling Zhang1
1Shaanxi Provincial People’s Hospital, Xi’an, China, 2Philips Healthcare, Xi’an, China

Synopsis

Keywords: Brain Connectivity, fMRI (resting state)To investigate the functional abnormalities of brain networks and hub nodes damaged in T2DM patients with mild cognitive impairment (DMCI). We applied degree centrality (DC) and seed-based functional connectivity (FC) analysis to identify the abnormal hub nodes and the FC patterns of these hubs in DMCI patients. Our results indicated that DMCI patients showed extensive alterations in the visual and memory pathways, and these alterations were correlated with clinical/cognitive variables. These results suggested that vision and memory-related brain regions dysfunctions may be involved in the neuropathology of visuospatial and memory function impairment in DMCI patients.

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