Meeting Banner
Abstract #2855

Aberrant brain gray matter and functional networks topology in end stage renal disease patients with cognitive impairment

Jiahui Zheng1, Jiankun Dai2, Xiangxiang Wu1, and Haifeng Shi1
1Department of Radiology, The Affiliated Changzhou NO.2 People’s Hospital of Nanjing Medical University, changzhou, China, 2GE Healthcare, MR Research China, Beijing, China

Synopsis

Keywords: Brain Connectivity, fMRI (resting state)This study aimed to characterize the topological properties of gray matter (GM) and functional networks in end-stage renal disease (ESRD) patients undergoing maintenance hemodialysis to provide insights into the underlying mechanisms of cognitive impairment. Functional and GM networks were constructed based on resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion kurtosis imaging (DKI), respectively. Disrupted topological organizations were observed, as indicated by significantly altered global measures, nodal efficiency, and degree centrality, which may account for the progression of cognitive dysfunction. And implementation of prediction models based on neuroimaging metrics may provide more objective information to promote early diagnosis and intervention.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords