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Abstract #2893

Preoperative MRI-based radiomic-clinical nomogram to predict residual tumor for advanced high-grade serous ovarian carcinoma

Jingjing Lu1, Songqi Cai1, Fang Wang2, Pu-Yeh Wu3, Xianpan Pan2, Jinwei Qiang4, Haiming Li5, and Mengsu Zeng1
1Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China, 2Department of Research and Development, Shanghai United Imaging Intelligence Co., Ltd, Shanghai, China, 3GE Healthcare, Beijing, China, 4Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, China, 5Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China

Synopsis

Keywords: Machine Learning/Artificial Intelligence, Radiomics, Ovarian carcinoma, Residual tumor predictionResidual tumor (RT) status is associated with the prognosis and survival rate of patients with high-grade serous ovarian carcinoma (HGSOC). However, current RT status prediction approach through laparoscopy has disadvantages of invasiveness, high cost and incidence of tumor metastases. In this study, we proposed a radiomic-clinical nomogram, based on multiple-sequence MRI combined with score of abdominal metastases and clinical markers, for preoperative prediction of RT status. We demonstrated that the radiomic-clinical nomogram had satisfactory prediction performance in all cohorts (AUC = 0.900-0.936). The clinical application value of the nomogram was further confirmed by decision curves.

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