Abstract #2899

Six-fold enhancement in spatial-resolution of Pseudo-Continuous Arterial Spin Labeling Perfusion Mapping using a Cryogenic Coil at 9.4T

Sara Pires Monteiro^1,2, Lydiane Hirschler^3,4, Emmanuel L. Barbier⁴, Patrícia Figueiredo², and Noam Shemesh¹

¹Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal, ²Institute for Systems and Robotics - Lisboa and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal, ³C.J. Gorter MRI Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Inserm, Grenoble Institut des Neurosciences, Université Grenoble Alpes, Grenoble, France

Synopsis

Keywords: Data Acquisition, Arterial spin labelling, PreclinicalHigh resolution CBF mapping using ASL can benefit multitude applications, yet its spatiotemporal resolution is limited in pre-clinical settings and at higher fields. To address this issue, we explored the possibility of improving the resolution of pCASL by using a cryogenic coil at 9.4T in the rat brain. Compared to the current state-of-the-art measurements, we managed to enhance the resolution of pCASL images by a factor of at least 6. The interpulse phase optimizations applied at the labelling plane are crucial for higher and stable inversion efficiency.

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